Wednesday (March 13) is another day for the history books as white smoke emerged from the Sistine Chapel in Vatican City to indicate a new Pope has been elected.

Earlier in the day, 76-year-old Jorge Mario Bergoglio, who will now be known as Pope Francis I, was announced as the 266th pope of the Roman Catholic Church.

Of course, it wouldn't be a big announcement without the stars of Tinseltown taking to Twitter to voice their reactions.

Check out some of the serious and not-so-serious thoughts that celebs had to say below:

Neil Patrick Harris: New Pope news soon! You might want to follow @TheTweetOfGod for all papal updates. He has an “in”

Carson Daly: We have a pope!!!!!

Seth Rogen: There’s also white smoke coming out of my office, but nobody seems that excited about it. #pope

Joan Rivers: A new Pope has been chosen! I haven’t seen this many people transfixed by a puff of white smoke since the discovery of fire!

Craig Ferguson: Rumors already swirling in Hollywood that the new Pope will replace Leno on NBC at 1130.

Seth MacFarlane: To signal the conclave had not reached a decision, they released black smoke from a chimney and emptied 400 styrofoam cups into the street.

Rosie O’Donnell: Which guy got the white rose – it’s like the bachelor – Vatican style #popewatch

David Arquette: Don’t call the new pope Francis – his name is Frank – If you call him Francis he’s gonna kill you

Kathy Griffin: I haven’t been paying that much attention to my old religion lately. Is this guy single?

Steve Martin: The new Pope just called! The new Pope just called!

Eric Stonestreet: Did they just go to central casting to get the new pope?

Kristen Bell: Hahahaha "@jram23: Nice try #newpope. We have bigger news to sell today. #veronicamarsmovie #finally."

Melissa Joan Hart: New pope? White smoke? Who got the gig?

Kate Walsh: Popestars! HA. RT @Joan_Rivers: The Vatican has gone Hollywood. Forget the white smoke-the new Pope will be announced by Ryan Seacrest on…

George Lopez : Please call me Pope JORGE !